教师简介
沈秉谦,1980-84年就读于华东理工大学生物化学专业,1987年获得澳洲新南威尔士大学(University of New South Wales)生物工程硕士,1991年获得昆士兰大学(University of Queensland)化学工程博士;1991-93年在密歇根大学(University of Michigan)化学工程系从事博士后研究工作,参与了第一个干细胞生物反应器原型设计工作,也是最早从事基因治疗反转录病毒生产工艺开发的人员。1993-94年就职于生物技术公司Progenitor, Inc. (Scientist);1994-98年就职于生物技术公司Metabolex, Inc. (Group Leader);1998-2001年就职于Monsanto Co. (Senior Scientist)。在若干生物医药领域,如动物细胞培养、干细胞/组织工程、基因治疗、生物材料、纳米给药系统、药物筛选模型、生物检测等,积累了比较丰富的技术研发和项目管理经验,有些工作属于首创。按照中国科学院“引进国外杰出人才计划”,2001-08年任上海生命科学研究院研究员,中国科学院研究生院教授。2008年7月加入南开大学。
代表性论文
1.Bing Q. Shen, Steve Reid, Paul F. Greenfield (1992). Continuous monoclonal antibody production by a composite gel perfusion bioreactor in a protein-free medium, Animal Cell Technology: Basic & Applied Aspects, 4: 173-178.
2.Bing Q. Shen, Paul F. Greenfield, Steve Reid (1993). Examination of polysaccharides for their uses in hybridoma cell culture, Biotechnology Techniques, 7(3): 193-198.
3.Bing Q. Shen, Paul F. Greenfield, Steve Reid(1994). Calcium alginate immobilized hybridomas grown using a fluidized-bed perfusion system with a protein-free medium, Cytotechnology, 14: 109-117.
4.Bing Q. Shen, Paul F. Greenfield, Steve Reid (1994). Hybridoma cells in a protein-free medium within a composite gel perfusion bioreactor, Cytotechnology, 16: 51-58.
5. Bernhard O. Palsson,Bing Q. Shen, Mark E. Meyeroff, Marek Trojanowicz (1994). Simultaneous determination of ammonia nitrogen and L-glutamine in bioreactor media by flow injection analysis, Analyst, 118: 1361-1365.
6.Bing Q. Shen, Michael F. Clarke, Bernhard O. Palsson (1996). Kinetics of retroviral production from the amphotrophic ψCRIP murine producer cell line, Cytotechnology, 22: 185-195.
7. Xianghui Gong, Qiangyi Fang, Xuesen Li, Xiangzong Han, Yuyin Wu, Shengli Yang,Bing Q. Shen(2005). A high-throughput end-point assay for viable mammalian cells, Cytotechnology, 49: 51-58.
8. Xianghui Gong, Dongxiao Li, Xiangzong Han, Qiangyi Fang, Yuyin Wu, Shengli Yang,Bing Q. Shen(2006). Fed-batch culture optimization of a growth-associated hybridoma cell line, Cytotechnology, 52: 25-38.
9. Xiangzong Han, Lei Sun, Dongxiao Li, Qiangyi Fang, Shengli Yang,Bing Q. Shen(2007). Transient expression of osteopontin in HEK293 cells in serum-free culture, Enzyme & Microbial Technology, 41: 133-140.
专利授权
10.沈秉谦,朱蕾,呼吸到插管装置,ZL032315902
11.沈秉谦,生物多糖微胶囊及其制备方法和用途
12.沈秉谦,贡向辉,杨胜利,高通量哺乳动物细胞培养基优化方法,中国专利申请号(已公开)
13.沈秉谦,杨胜利,高通量细胞分离装置与使用方法,中国专利申请号(已公开)
14.沈秉谦,杨胜利,方强毅,一种哺乳动物细胞无血清培养基,中国专利申请号(已公开)
15.沈秉谦,杨胜利,海藻酸盐纳米胶囊及其制备方法,中国专利申请号(已公开)
16.Shen, Bingqian& YANG Shengli, Composition and method for preparing alginate nanocapsules, US Application No. 11/368743, filing date March 06, 2006.